The Yeast Genomics* lab @ NOVA

(*evolutionary, functional, comparative and more)

People

Celso Almeida

Postdoctoral Fellow

Lab: (+351) 21 294 85 30 (ext. 11108)

Email: ch.almeida@campus.fct.unl.pt

MSc in Biodiversity of Natural Products, University of Leiden, The Netherlands, 2005

PhD in Pharmaceutical Biology, University of Bonn, Germany, 2011

Publications

Almeida C, El Maddah F, Kehraus S, Schnakenburg G, König GM. 2016. Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp. Org Lett. 18:528-31.

DOI:10.1021/acs.orglett.5b03553.

Almeida C*, Ortega H, Higginbotham S, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. 2014. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Lett Appl Microbiol. 59:58-64.

DOI: 10.1111/lam.12245.

 

Almeida C*, El Aouad N, Martín J, Pérez-Victoria I, González-Menéndez V, Platas G, de la Cruz M, Monteiro MC, de Pedro N, Bills GF, Vicente F, Genilloud O, Reyes F. 2014. Graminin B, a furanone from the fungus Paraconiothyrium sp. J Antibiot (Tokyo) 67:421-3.

DOI: 10.1038/ja.2014.11.

Bouhired SM, Crüsemann M, Almeida C, Weber T, Piel J, Schäberle TF, König GM. 2014. Biosynthesis of phenylnannolone A, a multidrug resistance reversal agent from the halotolerant myxobacterium Nannocystis pusilla B150. Chembiochem 15:757-65.

DOI: 10.1002/cbic.20130067.

Schmitz A, Kehraus S, Schäberle TF, Neu E, Almeida C, Roth M, König GM. 2014. Corallorazines from the myxobacterium Corallococcus coralloides. J Nat Prod. 77:159-63.

DOI: 10.1021/np400740u.

Almeida C, Eguereva E, Kehraus S, König GM. Unprecedented polyketides from a marine sponge-associated Stachylidium sp. 2013. J Nat Prod. 76:322-6.

DOI: 10.1021/np300668j.

Almeida C, Hemberger Y, Schmitt SM, Bouhired S, Natesan L, Kehraus S, Dimas K, Gütschow M, Bringmann G, König GM. 2012. Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. Chemistry 18:8827-34.

DOI: 10.1002/chem.201103278.

Almeida C, Part N, Bouhired S, Kehraus S, König GM. Stachylines A-D from the sponge-derived fungus Stachylidium sp. 2011. J Nat Prod. 74:21-5.

DOI: 10.1021/np1005345.

Almeida C, Kehraus S, Prudêncio M, König GM. Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp. 2011. Beilstein J Org Chem. 7:1636-42.

DOI: 10.3762/bjoc.7.192.

Almeida C, Elsaedi S, Kehraus S, König GM. 2010. Novel bisabolane sesquiterpenes from the marine-derived fungus Verticillium tenerum. Nat Prod Commun. 5:507-10.

Almeida C, Eguereva E, Kehraus S, Siering C, König GM. 2010. Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum. J Nat Prod. 73:476-8.

DOI: 10.1021/np900608d.

Bauvois C, Ibuka AS, Almeida C, Alba J, Ishii Y, Frère JM, Galleni M. 2005. Kinetic properties of four plasmid-mediated AmpC beta-lactamases. Antimicrob Agents Chemother. 49:4240-6.

DOI: 10.1128/AAC.49.10.4240-4246.2005

(*co-corresponding author)

Research interests

I am interested in two main topics: discovering new natural products from microorganisms and understanding symbioses between fungi and intracellular bacteria.

In natural products discovery, my focus is to find new bioactive secondary metabolites from microorganisms with pharmaceutical, agrochemical or cosmetic applications. At the moment I have isolated and identified more than 40 new natural products from Fungi and Bacteria, most of them with biological activity, and two groups of chemical families are currently in in vivo assays for potential patent applications.

My current research topic is the study of symbioses of endobacteria living in the intracellular space of fungi, where they are vertically inherited within fungal conidia (spores). My goal is not only to shed light on their biology, but also to detect new secondary metabolites produced by these intracellular bacteria. I am conducting experiments with the fungus Stachylidium bicolor, which seems to be a meta-organism composed by several endosymbiotic bacterial species.