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Isabel Sá Nogueira

Isabel de Sá Nogueira     cv

Associate Professor w. Agregação

PhD in Biology - Molecular Biology, 1991 (UNL)
Agregação (Habilitation) in Microbiology, Molecular Genetics and Molecular Biology, 2012 (UNL)

CREM, Dep. Ciências da Vida (DCV)
Faculdade de Ciências e Tecnologia
Universidade Nova de Lisboa
Quinta da Torre
2829-516 Caparica

Email: isn@fct.unl.pt

Telephone Nº: (+351) 212 948 500; ext.11107



Research Topic
The research in our laboratory focuses on the mechanisms that control gene expression. The main area of interest is to understand how the transcriptional and translational regulatory networks interact with other cellular components such as the metabolic system. This involves the analysis of the mechanisms through which the cell senses nutrient availability and transmits that information to the level of gene expression. It also involves looking at the transcription and translation control, which govern the expression of genes involved in carbohydrate metabolism.


Research Team
Isabel de Sá- Nogueira, PhD, Head of Laboratory
Mª Isabel Correia, PhD student
Mário Ferreira, PhD student
Lia Godinho, PhD student
Viviana Correia, MSc student
Sónia Silva, MSc student (co-supervision M. Alexandra Fernandes, Pedro Vidinha)

Current Funding

  • Breaking Down the Wall - Microbial Hemicellulases for saccharification, Fundação para a Ciência e a Tecnologia PTDC/AGR-AAM/102345/2008. Principal Investigator: Isabel de Sá Nogueira (2010-2012).

  • Redox-BioMaterials: Design of new redox biomaterials and their application in Biofuel cells for the production of electrical energy, feedstock chemicals and building blocks, Fundação para a Ciência e a Tecnologia PTDC/EBB-EBI/099237/2008. Principal: Investigator Luís Fonseca (IST/UTL) – 2010-2012.

  • Sol-gel entrapped cutinase: Understanding enzyme/matrix interactions via fluorescence, NMR and DRIFT spectroscopies, and site-directed mutagenesis, Fundação para a Ciência e a Tecnologia PPTDC/QUI/64744/2006. Principal Investigator: Susana F. Barreiros (FCT/UNL) - 2009-2012.

Selected publications

    Godinho LM, and de Sá-Nogueira I. (2011) Characterization and regulation of a bacterial sugar phosphatase of the HAD superfamily AraL from Bacillus subtilis. FEBS Journal 278: 2511-2524.

    Ferreira M.J. and I. de Sá-Nogueira (2010) A multitask ATPase serving different ABC-type sugar importers in Bacillus subtilis. Journal of Bacteriology 192 (20): 5312-5318.

    de Sanctis, D., Inácio, J., Lindley, P., de Sá-Nogueira I. and Bento, I. (2010) New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases. FEBS Journal 277(21): 4562-4574.

    Inácio, JM, Correia, I.L. and de Sá-Nogueira I (2008) Two distinct arabinofuranosidases contribute to arabino-oligosaccharide degradation in Bacillus subtilis. Microbiology-SGM 154 (9): 2719-2729.

    de Sanctis D, Bento I, Inácio JM, Custódio S, de Sá-Nogueira I, and Carrondo MA (2008) Overproduction, crystallization and preliminary X-ray characterization of Abn2, an endo-1,5-alpha-arabinanase from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 7): 636-638.

    Inácio, J.M., and I. de Sá-Nogueira (2008) Characterization of the abn2(yxiA) encoding a Bacillus subtilis GH43 arabinanase, Abn2, and its role in arabino-polysaccharides degradation. Journal of Bacteriology 190: 4272-4280.

    Franco, S. I., Mota, L. J., Soares, C. M., and de Sá-Nogueira I. (2007) Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon. Nucleic Acids Research 35: 4755-4766.

    Inácio J. M. and de Sá-Nogueira I. (2007) "trans-acting factors and cis elements involved in glucose repression of arabinan degradation in Bacillus subtilis. Journal of Bacteriology 189(22): 8371-8376.



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