Ilda Santos Sanches
This group combines researchers aiming to understand the mechanisms underlying the performance of microorganisms in
different natural and human-made environments. To that purpose different microbial models are used, from bacteria to
fungi, including yeasts, and different perspectives and approaches (ecological, physiological, biochemical, molecular
and genetic) are integrated.
Duarte Oliveira |
Helena Maria de Sousa |
Isabel Couto |
Isabel Sá Nogueira |
Madalena Oom |
Maria da Luz Martins |
Maria Luisa Vieira |
Rita Castro |
Rita Sobral |
This research group is divided in two main topics:
(i) Physiology and molecular biology of model microorganisms (gram-positive bacteria and fermentative yeasts) to
elucidate the molecular mechanisms of polysaccharide degradation, sugar metabolism and regulation and to investigate
mechanisms underlying cellular stress-response and adaptation to antibiotics.
(ii) Exploration of the molecular epidemiology and genetics of clinically relevant bacteria and fungi, in order to
identify epidemic/virulent clones, trace their spread and characterize genes involved in antibiotic resistance or virulence.
The development of molecular methods for reliable detection and differentiation is also envisioned.
Model organisms include Bacillus subtilis, Staphylococcus aureus, streptococcal species (S. pyogenes,
S. dysgalactiae and S. agalactiae), sexually transmitted and zoonotic bacteria, pathogenic fungi and
Project "Study of evasion mechanisms to innate immunity in group B streptococcal infections: identification of novel
therapeutic targets”. Ref PTDC/SAU-MII/105114/2008. Fundação para a Ciência e a Tecnologia, Portugal. January 1,
2010 – December 31, 2012. PI: Ilda Santos Sanches. Participant: M.J. Borrego, INSA, Portugal.
Project "Genomic study of Brucella suis biovar 2 Iberian strains." Ref PTDC/CVT/104050/2008. Fundação para a Ciência
e a Tecnologia, Portugal. 2010-2012. Member of research team: Participant: I.Santos Sanches, PI: R. Tenreiro, FFCUL (BioFIG),
Project “Fullerene-based systems for oxidative inactivation of airborne microbial pathogens - NANO-GUARD",
Ref PIRSES-GA-2010-269138. EU's Seventh framework programme (FP7). Marie Curie International Research Staff Exchange
Scheme. October 1, 2010 – September 30, 2015. Participant: I. Santos Sanches; Coordinator: S. Lyubchik, FCT/UNL
Breaking Down the Wall - Microbial Hemicellulases for saccharification, Fundação para a Ciência e a Tecnologia
PTDC/AGR-AAM/102345/2008 (2010-2012) PI: I. Sá-Nogueira.
Redox-BioMaterials: Design of new redox biomaterials and their application in Biofuel cells for the production
of electrical energy, feedstock chemicals and building blocks, Fundação para a Ciência e a Tecnologia
PTDC/EBB-EBI/099237/2008 (2010-2012). Member of research team: I Sá-Nogueira, PI: Luís Fonseca, IST/UTL, Portugal.
Sol-gel entrapped cutinase: Understanding enzyme/matrix interactions via fluorescence, NMR and DRIFT spectroscopies,
and site-directed mutagenesis, Fundação para a Ciência e a Tecnologia PPTDC/QUI/64744/2006 (2009-2012). Member of
research team: I Sá-Nogueira, PI: Susana Barreiros, FCT/UNL, Portugal
Contribution to the study of the association between multiple sclerosis and Lyme disease: laboratory, clinical and
eco-epidemiological aspects, ref EMBLYME-IHMT 01/10 (2010-2012). PI: ML Vieira
Emerging Aspects of human leptospirosis in São Miguel: new insights into the parasite – host relationship, Fundação
Calouste Gulbenkian, ref FCG-P-99888 (2009-2012). Participant: ML Vieira, PI: Luisa Mota-Vieira (Unidade de Genética
e Patologia Moleculares, Hosp. Divino Espírito Santo, São Miguel, Azores
Metabolic circuits in inflicted bacterial cell death, Fundação para a Ciência e Tecnologia PTDC/BIA-MIC/101375/2008
(2010-2012). PI: R. Sobral.
Association of extracellular DNA to the Staphylococcus aureus surface: roles and mechanisms. ESCMID research grant
(2011-2013). PI: R G. Sobral.
“Role of beta-lactamase operon in the stabilization and expression of methicillin resistance in Staphylococcus aureus”,
Fundação para a Ciência e Tecnologia, Lisbon, Portugal; Project: PTDC/BIA-MIC/64071/2006 (2008-2012); PI: Duarte C. Oliveira.